Difluoro-C4'-oxidized abasic site for efficient amine modification in biological systems.

Authors :: Yang B
Jinnouchi A
Suemune H
Aso M
Source :: Organic letters [Org Lett] 2012 Dec 07; Vol. 14 (23), pp. 5852-5. Date of Electronic Publication: 2012 Nov 14.
Publication Year :: 2012
Abstract: An oligodeoxynucleotide (ODN) containing a 2',2'-difluorinated analogue of a C4'-oxidized abasic site (C4'-OAS) was designed for the amine modification of biomolecules that interact with nucleic acids. In contrast to the parent C4'-OAS, which yielded amine-modified products accompanied by DNA strand scission, the ODN containing the difluoro C4'-OAS efficiently yielded products carrying ODNs. The amine modification proceeded without additional reagents being required and might be applicable to reactions in biological systems.

Subjects :: DNA chemistry
DNA Damage
Hydrocarbons, Fluorinated chemistry
Hydrocarbons, Fluorinated radiation effects
Molecular Structure
Oligodeoxyribonucleotides chemistry
Oligodeoxyribonucleotides radiation effects
Oxidation-Reduction
Amines chemistry
Hydrocarbons, Fluorinated chemical synthesis
Oligodeoxyribonucleotides chemical synthesis

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