Synthesis of fluorescent ristocetin aglycon derivatives with remarkable antibacterial and antiviral activities.

Authors :: Sipos A
Máté G
Rőth E
Borbás A
Batta G
Bereczki I
Kéki S
Jóna I
Ostorházi E
Rozgonyi F
Vanderlinden E
Naesens L
Herczegh P
Source :: European journal of medicinal chemistry [Eur J Med Chem] 2012 Dec; Vol. 58, pp. 361-7. Date of Electronic Publication: 2012 Oct 25.
Publication Year :: 2012
Abstract: Isoindole and benzoisoindole derivatives of ristocetin aglycon have been prepared by reaction with o-phthalaldehyde or naphthalene-2,3-dialdehyde and various thiols. The new compounds exhibited potent antibacterial and anti-influenza virus activity. The cluster forming and fluorescent properties of the aglycon derivatives were also studied.<br /> (Copyright © 2012 Elsevier Masson SAS. All rights reserved.)

Subjects :: Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents chemistry
Antiviral Agents chemical synthesis
Antiviral Agents chemistry
Dose-Response Relationship, Drug
Doxorubicin chemical synthesis
Doxorubicin chemistry
Doxorubicin pharmacology
Microbial Sensitivity Tests
Molecular Conformation
Structure-Activity Relationship
Anti-Bacterial Agents pharmacology
Antiviral Agents pharmacology
Doxorubicin analogs & derivatives
Fluorescence
Gram-Positive Bacteria drug effects
Orthomyxoviridae drug effects

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