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Diastereoselective and enantioselective desymmetrization of α-substituted cyclohexadienones via intramolecular Stetter reaction.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2012 Dec 07; Vol. 77 (23), pp. 10996-1001. Date of Electronic Publication: 2012 Nov 16. - Publication Year :
- 2012
-
Abstract
- Highly diastereoselective and enantioselective desymmetrization of α-substituted cyclohexadienones via NHC-catalyzed intramolecular Stetter reaction was realized. Amino-indanol derived triazolium salt bearing a C(6)F(5) group was found to be the optimal catalyst precursor in the intramolecular Stetter reaction furnishing tricyclic products bearing multi-stereocenters in up to 96% yield and >99% ee.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 77
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 23140505
- Full Text :
- https://doi.org/10.1021/jo3022555