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Massive splenomegaly in acute erythroid leukaemia (FAB Class-M6): an unusual presentation.

Massive splenomegaly in acute erythroid leukaemia (FAB Class-M6): an unusual presentation.

Authors :
Sherazi SF
Butt Z
Source :
JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2012 Sep; Vol. 62 (9), pp. 989-90.
Publication Year :
2012

Abstract

AML-M6 has a peak incidence in the seventh decade with slight male preponderance, and can also present at a younger age. The usual features are anaemia, thrombocytopenia, malaise, fatigue, easy bruising, epistaxis and petechiae. Splenomegaly may occur in 20-40 % of the cases but massive splenomegaly is rare presentation and have been only reported once in humans and once in animals. A 22 year Asian female, presented with fatigue, pallor, mild jaundice, exertional dyspnoea, epigastric pain, tender right hypochondrium and massive splenomegaly. Investigations revealed anaemia and thrombocytopenia, tear drop cells, basophilic stippling, piokilocytosis and anisochromia; increased uric acid and LDH. Abdominal ultrasound showed enlarged liver (22cm) and spleen (20cm). Bone marrow aspiration revealed 51% erythroid and 24% non-erythroid precursors, depressed leukopoeisis and megakarypoeisis. Erythroblasts were PAS and CD71 positive and also reacted to Antihaemoglobin-Antibody. This report highlights characteristic features and diagnostic criteria of erythroleukaemia, differential diagnosis of massive splenomegaly and their rare association.

Details

Language :
English
ISSN :
0030-9982
Volume :
62
Issue :
9
Database :
MEDLINE
Journal :
JPMA. The Journal of the Pakistan Medical Association
Publication Type :
Academic Journal
Accession number :
23139997