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Massive splenomegaly in acute erythroid leukaemia (FAB Class-M6): an unusual presentation.
Massive splenomegaly in acute erythroid leukaemia (FAB Class-M6): an unusual presentation.
- Source :
-
JPMA. The Journal of the Pakistan Medical Association [J Pak Med Assoc] 2012 Sep; Vol. 62 (9), pp. 989-90. - Publication Year :
- 2012
-
Abstract
- AML-M6 has a peak incidence in the seventh decade with slight male preponderance, and can also present at a younger age. The usual features are anaemia, thrombocytopenia, malaise, fatigue, easy bruising, epistaxis and petechiae. Splenomegaly may occur in 20-40 % of the cases but massive splenomegaly is rare presentation and have been only reported once in humans and once in animals. A 22 year Asian female, presented with fatigue, pallor, mild jaundice, exertional dyspnoea, epigastric pain, tender right hypochondrium and massive splenomegaly. Investigations revealed anaemia and thrombocytopenia, tear drop cells, basophilic stippling, piokilocytosis and anisochromia; increased uric acid and LDH. Abdominal ultrasound showed enlarged liver (22cm) and spleen (20cm). Bone marrow aspiration revealed 51% erythroid and 24% non-erythroid precursors, depressed leukopoeisis and megakarypoeisis. Erythroblasts were PAS and CD71 positive and also reacted to Antihaemoglobin-Antibody. This report highlights characteristic features and diagnostic criteria of erythroleukaemia, differential diagnosis of massive splenomegaly and their rare association.
- Subjects :
- Abdominal Pain etiology
Abdominal Pain pathology
Abdominal Pain physiopathology
Anemia diagnosis
Anemia etiology
Antigens, CD metabolism
Diagnosis, Differential
Female
Humans
Organ Size
Receptors, Transferrin metabolism
Ultrasonography
Young Adult
Abdominal Pain diagnostic imaging
Bone Marrow pathology
Erythroblasts metabolism
Erythroblasts pathology
Hematologic Tests methods
Leukemia, Erythroblastic, Acute complications
Leukemia, Erythroblastic, Acute diagnosis
Leukemia, Erythroblastic, Acute physiopathology
Splenomegaly diagnosis
Splenomegaly etiology
Splenomegaly pathology
Splenomegaly physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0030-9982
- Volume :
- 62
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- JPMA. The Journal of the Pakistan Medical Association
- Publication Type :
- Academic Journal
- Accession number :
- 23139997