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Copeptin in acute chest pain: identification of acute coronary syndrome and obstructive coronary artery disease on coronary CT angiography.
- Source :
-
Emergency medicine journal : EMJ [Emerg Med J] 2013 Nov; Vol. 30 (11), pp. 910-3. Date of Electronic Publication: 2012 Nov 08. - Publication Year :
- 2013
-
Abstract
- Objective: To determine the diagnostic accuracy of copeptin in patients with suspected acute coronary syndrome (ACS) and its correlation with obstructive coronary artery disease (CAD) on coronary CT angiography (CTA).<br />Methods: Copeptin was measured at arrival in 65 consecutive patients (56 ± 10 years, 45 men) suspected of ACS and no indication for immediate invasive angiography. All patients underwent coronary CTA without disclosure of the results to the treating physician, and outcomes were classified as obstructive CAD (>50% stenosis) or no obstructive CAD (≤ 50%) in one or more vessel.<br />Results: The final diagnosis of ACS was established in 10 (15%) patients, 6 myocardial infarctions and 4 unstable angina pectoris. Coronary CTA detected obstructive CAD in all patients with ACS and in 10 (15%) patients with no ACS. Copeptin concentrations were higher in patients with ACS (median 7.42 pmol/l (IQR 3.71-18.72)) vs patients with no ACS (3.40 pmol/l (1.13-6.27), p=0.02). Copeptin was not higher in patients with obstructive CAD on coronary CTA (4.87 pmol/l (2.90-8.51) vs 3.60 pmol/l (1.21-6.23), p=0.20) compared with patients with no obstructive CAD.<br />Conclusions: Copeptin seems to be elevated in patients with ACS while there is no strong correlation with obstructive coronary disease on CTA.
- Subjects :
- Acute Coronary Syndrome blood
Aged
Analysis of Variance
Biomarkers blood
Chest Pain blood
Coronary Artery Disease blood
Female
Humans
Male
Middle Aged
Prospective Studies
Sensitivity and Specificity
Acute Coronary Syndrome diagnosis
Chest Pain diagnosis
Coronary Angiography
Coronary Artery Disease diagnosis
Glycopeptides blood
Tomography, X-Ray Computed
Subjects
Details
- Language :
- English
- ISSN :
- 1472-0213
- Volume :
- 30
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Emergency medicine journal : EMJ
- Publication Type :
- Academic Journal
- Accession number :
- 23139095
- Full Text :
- https://doi.org/10.1136/emermed-2012-201596