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Copeptin in acute chest pain: identification of acute coronary syndrome and obstructive coronary artery disease on coronary CT angiography.

Authors :
Dedic A
ten Kate GJ
Rood PP
Galema TW
Ouhlous M
Moelker A
de Feyter PJ
de Rijke YB
Nieman K
Source :
Emergency medicine journal : EMJ [Emerg Med J] 2013 Nov; Vol. 30 (11), pp. 910-3. Date of Electronic Publication: 2012 Nov 08.
Publication Year :
2013

Abstract

Objective: To determine the diagnostic accuracy of copeptin in patients with suspected acute coronary syndrome (ACS) and its correlation with obstructive coronary artery disease (CAD) on coronary CT angiography (CTA).<br />Methods: Copeptin was measured at arrival in 65 consecutive patients (56 ± 10 years, 45 men) suspected of ACS and no indication for immediate invasive angiography. All patients underwent coronary CTA without disclosure of the results to the treating physician, and outcomes were classified as obstructive CAD (>50% stenosis) or no obstructive CAD (≤ 50%) in one or more vessel.<br />Results: The final diagnosis of ACS was established in 10 (15%) patients, 6 myocardial infarctions and 4 unstable angina pectoris. Coronary CTA detected obstructive CAD in all patients with ACS and in 10 (15%) patients with no ACS. Copeptin concentrations were higher in patients with ACS (median 7.42 pmol/l (IQR 3.71-18.72)) vs patients with no ACS (3.40 pmol/l (1.13-6.27), p=0.02). Copeptin was not higher in patients with obstructive CAD on coronary CTA (4.87 pmol/l (2.90-8.51) vs 3.60 pmol/l (1.21-6.23), p=0.20) compared with patients with no obstructive CAD.<br />Conclusions: Copeptin seems to be elevated in patients with ACS while there is no strong correlation with obstructive coronary disease on CTA.

Details

Language :
English
ISSN :
1472-0213
Volume :
30
Issue :
11
Database :
MEDLINE
Journal :
Emergency medicine journal : EMJ
Publication Type :
Academic Journal
Accession number :
23139095
Full Text :
https://doi.org/10.1136/emermed-2012-201596