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Effect of asiatic and ursolic acids on morphology, hydrophobicity, and adhesion of UPECs to uroepithelial cells.
- Source :
-
Folia microbiologica [Folia Microbiol (Praha)] 2013 May; Vol. 58 (3), pp. 245-52. Date of Electronic Publication: 2012 Nov 07. - Publication Year :
- 2013
-
Abstract
- Adhesion of bacteria to epithelial tissue is an essential step in the progression of the urinary tract infections. Reduction of virulence factors responsible for microbial attachment may help to decrease or inhibit colonization of the host organism by pathogens. In the age of increasing bacterial antibiotic resistance, more and more attention is being paid to the use of plants and/or their bioactive components in the prevention and treatment of human infections. Asiatic acid (AA) and ursolic acid (UA), two plant secondary metabolites, were used as potential antibacterial agents. The current study aimed to determine the possible impact of AA and UA on morphology, hydrophobicity, and adhesion of clinical uropathogenic Escherichia coli strains (UPEC) to the uroepithelial cells. Our work describes for the first time the effects exerted by AA and UA on virulence factors of UPECs. The impact of both acids on the cell surface hydrophobicity of the investigated strains was very weak. The results clearly show the influence of AA and UA on the presence of P fimbriae and curli fibers, morphology of the UPECs cells and their adhesion to epithelium; however, some differences between activities of AA and UA were found.
- Subjects :
- Anti-Bacterial Agents pharmacology
Cells, Cultured
Epithelial Cells cytology
Female
Humans
Microbial Sensitivity Tests
Pentacyclic Triterpenes pharmacology
Phylogeny
Plant Extracts pharmacology
Sequence Analysis, DNA
Uropathogenic Escherichia coli growth & development
Urothelium microbiology
Virulence Factors
Ursolic Acid
Bacterial Adhesion drug effects
Epithelial Cells microbiology
Hydrophobic and Hydrophilic Interactions drug effects
Triterpenes pharmacology
Uropathogenic Escherichia coli drug effects
Urothelium cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1874-9356
- Volume :
- 58
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Folia microbiologica
- Publication Type :
- Academic Journal
- Accession number :
- 23132656
- Full Text :
- https://doi.org/10.1007/s12223-012-0205-7