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Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2012 Dec; Vol. 58, pp. 287-98. Date of Electronic Publication: 2012 Oct 18. - Publication Year :
- 2012
-
Abstract
- The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.<br /> (Copyright © 2012 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Acetic Acid
Animals
Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics
Carrageenan antagonists & inhibitors
Carrageenan pharmacology
Constriction, Pathologic chemically induced
Dose-Response Relationship, Drug
Enzyme Inhibitors pharmacokinetics
Isoenzymes antagonists & inhibitors
Isoenzymes metabolism
Male
Mice
Molecular Structure
Muscle, Smooth, Vascular chemistry
Muscle, Smooth, Vascular drug effects
Muscle, Smooth, Vascular metabolism
Rats
Rats, Sprague-Dawley
Rats, Wistar
Solubility
Structure-Activity Relationship
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Constriction, Pathologic drug therapy
Cyclooxygenase 2 metabolism
Enzyme Inhibitors chemistry
Enzyme Inhibitors pharmacology
Nitric Oxide metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1768-3254
- Volume :
- 58
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 23131542
- Full Text :
- https://doi.org/10.1016/j.ejmech.2012.10.014