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Medications development for opioid abuse.
- Source :
-
Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2013 Jan 01; Vol. 3 (1), pp. a012104. Date of Electronic Publication: 2013 Jan 01. - Publication Year :
- 2013
-
Abstract
- Here we describe methods for preclinical evaluation of candidate medications to treat opioid abuse and dependence. Our perspective is founded on the propositions that (1) drug self-administration procedures provide the most direct method for assessment of medication effects, (2) procedures that assess choice between opioid and nondrug reinforcers are especially useful, and (3) the states of opioid dependence and withdrawal profoundly influence both opioid reinforcement and the effects of candidate medications. Effects of opioid medications on opioid choice in nondependent and opioid-dependent subjects are reviewed. Various nonopioid medications have also been examined, but none yet have been identified that safely and reliably reduce opioid choice. Future research will focus on (1) strategies for increasing safety and/or effectiveness of opioid medications, and (2) continued development of nonopioids such as inhibitors of endocannabinoid catabolic enzymes or inhibitors of opioid-induced glial activation.
- Subjects :
- Analgesics, Opioid administration & dosage
Buprenorphine therapeutic use
Choice Behavior
Endocannabinoids therapeutic use
Evidence-Based Medicine
Humans
Methadone therapeutic use
Naltrexone therapeutic use
Narcotic Antagonists administration & dosage
Narcotic Antagonists pharmacology
Narcotics administration & dosage
Neuroglia drug effects
Opioid-Related Disorders etiology
Reinforcement, Psychology
Self Administration
Substance Withdrawal Syndrome prevention & control
Treatment Outcome
Analgesics, Opioid agonists
Analgesics, Opioid therapeutic use
Narcotic Antagonists therapeutic use
Narcotics agonists
Narcotics therapeutic use
Opioid-Related Disorders drug therapy
Receptors, Opioid, mu drug effects
Substance Withdrawal Syndrome drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2157-1422
- Volume :
- 3
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cold Spring Harbor perspectives in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 23125072
- Full Text :
- https://doi.org/10.1101/cshperspect.a012104