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Briacavatolides D-F, new briaranes from the Taiwanese octocoral Briareum excavatum.
- Source :
-
Marine drugs [Mar Drugs] 2012 Sep; Vol. 10 (9), pp. 2103-2110. Date of Electronic Publication: 2012 Sep 24. - Publication Year :
- 2012
-
Abstract
- In the continued search for novel bioactive substances from the Taiwanese octocoral Briareum excavatum collected at Orchid Island, three new briarane-type diterpenoids, briacavatolides D-F (1-3) were isolated from the acetone extract. The structures of these compounds were elucidated by extensive NMR spectroscopic analysis and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-3 and their cytotoxicity against selected cancer cell lines were evaluated.
- Subjects :
- Animals
Antiviral Agents chemistry
Antiviral Agents pharmacology
Cell Line, Tumor
Cytomegalovirus drug effects
HT29 Cells
Humans
Magnetic Resonance Spectroscopy methods
Mice
Taiwan
Anthozoa chemistry
Aquatic Organisms chemistry
Biological Products chemistry
Biological Products pharmacology
Diterpenes chemistry
Diterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 10
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 23118724
- Full Text :
- https://doi.org/10.3390/md10092103