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Relationship between oxygen consumption kinetics and BODE Index in COPD patients.
- Source :
-
International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2012; Vol. 7, pp. 711-8. Date of Electronic Publication: 2012 Oct 17. - Publication Year :
- 2012
-
Abstract
- Background and Objective: Patients with chronic obstructive pulmonary disease (COPD) present with reduced exercise capacity due to impaired oxygen consumption (VO(2)), caused primarily by pulmonary dysfunction and deleterious peripheral adaptations. Assuming that COPD patients present with slower VO(2) and heart rate (HR) on-kinetics, we hypothesized that this finding is related to disease severity as measured by the BODE Index. In this context, the present study intends to evaluate the relationship between VO(2) uptake on-kinetics during high-intensity exercise and the BODE Index in patients with COPD.<br />Methods: Twenty males with moderate-to-severe stable COPD and 13 healthy control subjects matched by age and sex were evaluated. COPD patients were screened by the BODE Index and then underwent an incremental cardiopulmonary exercise test and a constant speed treadmill session at 70% of maximal intensity for 6 minutes. The onset of the exercise (first 360 seconds) response for O(2) uptake and HR was modeled according to a monoexponential fit.<br />Results: Oxygen consumption and HR on-kinetics were slower in the COPD group compared with controls. Additionally, VO(2) on-kinetic parameters revealed a strong positive correlation (r = 0.77, P < 0.05) with BODE scores and a moderate negative correlation with walking distance (r = -0.45, P < 0.05).<br />Conclusion: Our data show that moderate-to-severe COPD is related to impaired oxygen delivery and utilization during the onset of intense exercise.
- Subjects :
- Aged
Body Mass Index
Case-Control Studies
Dyspnea diagnosis
Dyspnea metabolism
Dyspnea physiopathology
Forced Expiratory Volume
Heart Rate
Humans
Kinetics
Male
Middle Aged
Predictive Value of Tests
Pulmonary Disease, Chronic Obstructive metabolism
Pulmonary Disease, Chronic Obstructive physiopathology
Severity of Illness Index
Vital Capacity
Breath Tests
Exercise Test
Exercise Tolerance
Lung physiopathology
Muscle Contraction
Muscle, Skeletal metabolism
Oxygen Consumption
Pulmonary Disease, Chronic Obstructive diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2005
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- International journal of chronic obstructive pulmonary disease
- Publication Type :
- Academic Journal
- Accession number :
- 23118534
- Full Text :
- https://doi.org/10.2147/COPD.S35637