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Elimination of intracellularly residing Mycobacterium tuberculosis through targeting of host and bacterial signaling mechanisms.
- Source :
-
Expert review of anti-infective therapy [Expert Rev Anti Infect Ther] 2012 Sep; Vol. 10 (9), pp. 1007-22. - Publication Year :
- 2012
-
Abstract
- With more than 2 billion latently infected people, TB continues to represent a serious threat to human health. According to the WHO, 1.1 million people died from TB in 2010, which is equal to approximately 3000 deaths per day. The causative agent of the disease, Mycobacterium tuberculosis, is a highly successful pathogen having evolved remarkable strategies to persist within the host. Although normally, upon phagocytosis by macrophages, bacteria are readily eliminated by lysosomes, pathogenic mycobacteria actively prevent destruction within macrophages. The strategies that pathogenic mycobacteria apply range from releasing virulence factors to manipulating host molecules resulting in the modulation of host signal transduction pathways in order to sustain their viability within the infected host. Here, we analyze the current status of how a better understanding of both the bacterial and host factors involved in virulence can be used to develop drugs that may be helpful to curb the TB epidemic.
- Subjects :
- Antitubercular Agents chemistry
Antitubercular Agents therapeutic use
Bacterial Proteins chemistry
Bacterial Proteins genetics
Drug Resistance, Bacterial genetics
Drug Resistance, Bacterial physiology
Humans
Macrophages drug effects
Macrophages metabolism
Macrophages microbiology
Mycobacterium tuberculosis metabolism
Mycobacterium tuberculosis pathogenicity
Virulence
Antitubercular Agents pharmacology
Bacterial Proteins metabolism
Mycobacterium tuberculosis drug effects
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8336
- Volume :
- 10
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Expert review of anti-infective therapy
- Publication Type :
- Academic Journal
- Accession number :
- 23106276
- Full Text :
- https://doi.org/10.1586/eri.12.95