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The prostamide-related glaucoma therapy, bimatoprost, offers a novel approach for treating scalp alopecias.
- Source :
-
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2013 Feb; Vol. 27 (2), pp. 557-67. Date of Electronic Publication: 2012 Oct 26. - Publication Year :
- 2013
-
Abstract
- Balding causes widespread psychological distress but is poorly controlled. The commonest treatment, minoxidil, was originally an antihypertensive drug that promoted unwanted hair. We hypothesized that another serendipitous discovery, increased eyelash growth side-effects of prostamide F(2α)-related eyedrops for glaucoma, may be relevant for scalp alopecias. Eyelash hairs and follicles are highly specialized and remain unaffected by androgens that inhibit scalp follicles and stimulate many others. Therefore, we investigated whether non-eyelash follicles could respond to bimatoprost, a prostamide F(2α) analog recently licensed for eyelash hypotrichosis. Bimatoprost, at pharmacologically selective concentrations, increased hair synthesis in scalp follicle organ culture and advanced mouse pelage hair regrowth in vivo compared to vehicle alone. A prostamide receptor antagonist blocked isolated follicle growth, confirming a direct, receptor-mediated mechanism within follicles; RT-PCR analysis identified 3 relevant receptor genes in scalp follicles in vivo. Receptors were located in the key follicle regulator, the dermal papilla, by analyzing individual follicular structures and immunohistochemistry. Thus, bimatoprost stimulates human scalp follicles in culture and rodent pelage follicles in vivo, mirroring eyelash behavior, and scalp follicles contain bimatoprost-sensitive prostamide receptors in vivo. This highlights a new follicular signaling system and confirms that bimatoprost offers a novel, low-risk therapeutic approach for scalp alopecias.
- Subjects :
- Administration, Topical
Adult
Alopecia genetics
Alopecia metabolism
Amides administration & dosage
Animals
Antihypertensive Agents administration & dosage
Antihypertensive Agents therapeutic use
Base Sequence
Bimatoprost
Cloprostenol administration & dosage
Cloprostenol therapeutic use
Female
Glaucoma drug therapy
Hair Follicle drug effects
Hair Follicle growth & development
Hair Follicle metabolism
Humans
Immunohistochemistry
Male
Mice
Middle Aged
Organ Culture Techniques
RNA, Messenger genetics
RNA, Messenger metabolism
Receptors, Prostaglandin antagonists & inhibitors
Receptors, Prostaglandin drug effects
Receptors, Prostaglandin genetics
Receptors, Prostaglandin metabolism
Scalp drug effects
Scalp metabolism
Young Adult
Alopecia drug therapy
Amides therapeutic use
Cloprostenol analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1530-6860
- Volume :
- 27
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 23104985
- Full Text :
- https://doi.org/10.1096/fj.12-218156