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Mancozeb-induced behavioral deficits precede structural neural degeneration.
- Source :
-
Neurotoxicology [Neurotoxicology] 2013 Jan; Vol. 34, pp. 74-81. Date of Electronic Publication: 2012 Oct 24. - Publication Year :
- 2013
-
Abstract
- Manganese-containing fungicides like Mancozeb have been associated with neurodegenerative conditions like Parkinson's disease. We examined the behavioral damage and differential neuronal vulnerability resulting from Mancozeb exposure using Caenorhabditis elegans, an important mid-trophic level soil organism that is also a powerful model for studying mechanisms of environmental pollutant-induced neurodegenerative disease. The dopamine-mediated swim to crawl locomotory transition behavior is exquisitely vulnerable to Mancozeb, with functional impairment preceding markers of neuronal structural damage. The damage is partially rescued in mutants lacking the divalent metal transporter, SMF-1, demonstrating that some, but not all, of the damage is mediated by manganese. Increasing concentrations of Mancozeb recruit additional behavioral dysfunction, notably serotonin-mediated egg-laying behavior, but without evident serotonergic neuronal structural damage. Thus, measurements of behavioral dysfunction are a sensitive early marker of fungicide toxicity that could be exploited to examine further mechanisms of neuron damage and possible therapeutic interventions. These results also provide important insight into the consequences of fungicide use on the ecological behavior of nematodes.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Caenorhabditis elegans genetics
Caenorhabditis elegans metabolism
Caenorhabditis elegans Proteins genetics
Caenorhabditis elegans Proteins metabolism
Cation Transport Proteins genetics
Cation Transport Proteins metabolism
Dopamine metabolism
Dose-Response Relationship, Drug
Environmental Pollutants metabolism
Fungicides, Industrial metabolism
Locomotion drug effects
Maneb metabolism
Mechanotransduction, Cellular drug effects
Mutation
Neurons metabolism
Neurons pathology
Oviposition drug effects
Serotonin metabolism
Touch
Zineb metabolism
Behavior, Animal drug effects
Caenorhabditis elegans drug effects
Environmental Pollutants toxicity
Fungicides, Industrial toxicity
Maneb toxicity
Nerve Degeneration
Neurons drug effects
Zineb toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9711
- Volume :
- 34
- Database :
- MEDLINE
- Journal :
- Neurotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 23103283
- Full Text :
- https://doi.org/10.1016/j.neuro.2012.10.007