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Alum-adjuvanted H5N1 whole virion inactivated vaccine (WIV) induced IgG1 and IgG4 antibody responses in young children.
- Source :
-
Vaccine [Vaccine] 2012 Dec 14; Vol. 30 (52), pp. 7662-6. Date of Electronic Publication: 2012 Oct 24. - Publication Year :
- 2012
-
Abstract
- IgG subclass antibody responses are not fully understood. Alum-adjuvanted H5N1whole virion inactivated vaccine (WIV), a genetically reassortant vaccine seed strain originating from H5N1/A/Vietnam/1194/2004 and PR-8, induced significantly stronger antibody responses in neutralizing antibodies in children. In this report, IgG subclass antibody responses were investigated, and most serum samples were positive for IgG1 antibody before immunization. A significant response (more than 4-fold increase) of IgG1 antibody was observed in 67/193 (34.7%) and that of gG4 antibodies in 42/193(21.8%). Children <4 years of age showed a significant increase in IgG subclass antibodies but those ≥4 years showed lower responses. Alum- adjuvanted H5N1WIV induced an efficient immune response in young children especially <4 years.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Age Factors
Child
Child, Preschool
Humans
Infant
Influenza Vaccines administration & dosage
Vaccines, Inactivated administration & dosage
Vaccines, Inactivated immunology
Adjuvants, Immunologic administration & dosage
Alum Compounds administration & dosage
Antibodies, Viral blood
Immunoglobulin G blood
Influenza A Virus, H5N1 Subtype immunology
Influenza Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 30
- Issue :
- 52
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 23102974
- Full Text :
- https://doi.org/10.1016/j.vaccine.2012.10.006