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Endothelial function and cardiovascular risk in patients with idiopathic sudden sensorineural hearing loss.
- Source :
-
Atherosclerosis [Atherosclerosis] 2012 Dec; Vol. 225 (2), pp. 511-6. Date of Electronic Publication: 2012 Oct 11. - Publication Year :
- 2012
-
Abstract
- Objective: To evaluate cardiovascular risk factors and pre-clinical atherosclerosis in subjects affected by idiopathic sudden sensorineural hearing loss (ISSHL).<br />Methods: In this study, 29 ISSHL patients and 29 healthy controls were evaluated. All of the patients underwent a complete audiovestibular and clinical evaluation. Carotid intima-media thickness (C-IMT) and flow-mediated dilation (FMD) of the brachial artery were assessed as early markers of atherosclerosis.<br />Results: Our results showed that FMD was significantly lower in the ISSHL patients than in the controls (5.6 ± 1.6% vs. 7.7 ± 3.7%, p < 0.01). Moreover, the total cholesterol and low density lipoprotein cholesterol were significantly higher in the ISSHL patients than in the controls (p < 0.05). The two groups did not differ with regards to C-IMT and other cardiovascular risk factors. Vestibular involvement was shown to be associated with lower FMD values (4.1 ± 1.7% vs. 5.8 ± 1.5%, p < 0.05). No relationship was found between C-IMT and vestibular involvement. Finally, multiple logistic regression highlighted the finding that only FMD values seemed to predispose individuals to developing ISSHL (p = 0.03, OR: 1.4).<br />Conclusions: ISSHL seemed to be associated with vascular endothelial dysfunction and an increased cardiovascular risk, which supports the hypothesis of a vascular aetiology for this disease.<br /> (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Biomarkers blood
Brachial Artery diagnostic imaging
Carotid Arteries diagnostic imaging
Carotid Artery Diseases blood
Carotid Artery Diseases diagnosis
Carotid Artery Diseases physiopathology
Carotid Intima-Media Thickness
Case-Control Studies
Chi-Square Distribution
Cholesterol blood
Cholesterol, LDL blood
Early Diagnosis
Endothelium, Vascular diagnostic imaging
Female
Hearing Loss, Sensorineural diagnosis
Hearing Loss, Sensorineural physiopathology
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Predictive Value of Tests
Risk Assessment
Risk Factors
Brachial Artery physiopathology
Carotid Artery Diseases etiology
Endothelium, Vascular physiopathology
Hearing Loss, Sensorineural complications
Vasodilation
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 225
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 23102449
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2012.10.024