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Histologic findings in alcoholic liver disease.
- Source :
-
Clinics in liver disease [Clin Liver Dis] 2012 Nov; Vol. 16 (4), pp. 699-716. - Publication Year :
- 2012
-
Abstract
- The necessity of the liver being the organ responsible for metabolism of alcohol exposes it to many untoward toxic side effects. In the first instance of hepatic steatosis, fibrosis may occur indolently over years, slowly converting a greasy, steatotic liver into a cirrhotic liver. In the case of alcoholic hepatitis, brisk sinusoidal fibrosis may lead to more rapid development of cirrhosis, with the liver extensively subdivided by sublobular fibrous septa developing in the midst of extensive ongoing inflammation and hepatocellular destruction. Continued destruction of the parenchyma after cirrhosis has developed may produce a densely fibrotic organ with little remaining parenchyma.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- Apoptosis
Diagnosis, Differential
Disease Progression
Fatty Liver, Alcoholic metabolism
Fatty Liver, Alcoholic pathology
Hepatic Stellate Cells pathology
Hepatitis, Alcoholic metabolism
Hepatitis, Alcoholic pathology
Hepatocytes metabolism
Hepatocytes pathology
Humans
Inflammation pathology
Lipid Metabolism
Liver Cirrhosis, Alcoholic metabolism
Liver Cirrhosis, Alcoholic pathology
Liver Diseases, Alcoholic etiology
Liver Diseases, Alcoholic metabolism
Liver Regeneration
Mallory Bodies metabolism
Mallory Bodies pathology
Necrosis
Liver Diseases, Alcoholic pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8224
- Volume :
- 16
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Clinics in liver disease
- Publication Type :
- Academic Journal
- Accession number :
- 23101978
- Full Text :
- https://doi.org/10.1016/j.cld.2012.08.004