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Receptivity assessment of an ultrasonographic homogeneous endometrium in the late follicular phase of infertile women with natural cycles.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2012 Dec; Vol. 207 (6), pp. 511.e1-7. Date of Electronic Publication: 2012 Oct 01. - Publication Year :
- 2012
-
Abstract
- Objective: The purpose of this study was to assess the receptivity of the homogeneous endometrium in the late follicular phase in infertile women with natural cycles.<br />Study Design: Twenty-eight infertile women with ultrasonographically homogeneous (group 1) or trilaminar (group 2) endometria in the late follicular phase underwent endometrial biopsies. Some molecular markers and development of pinopodes were evaluated.<br />Results: In the late follicular phase, the mean level of vascular endothelial growth factor was significantly lower in group 1 than in group 2 (0.96 ± 0.37 marks vs 1.39 ± 0.46 marks; P = .010). In the mid luteal phase, a decreased leukemia inhibitory factor and integrin alpha v beta 3 levels were found in group 1 (1.58 ± 0.99 marks vs 2.59 ± 0.61 marks; 1.85 ± 0.72 marks vs 2.60 ± 0.73 marks; 1.92 ± 0.91 marks vs 2.83 ± 0.57 marks; P = .003; P = .011; P = .004). The rate of fully developed pinopodes in the mid luteal phase was significantly decreased in group 1 (P = .018).<br />Conclusion: An ultrasonographically homogeneous endometrium in the late follicular phase was associated with poor receptivity in infertile women with natural cycles.<br /> (Copyright © 2012 Mosby, Inc. All rights reserved.)
- Subjects :
- Adult
Biopsy
Endometrium physiopathology
Female
Gene Expression
Humans
Immunohistochemistry
Leukemia Inhibitory Factor genetics
Microscopy, Electron, Scanning
Ultrasonography
Vascular Endothelial Growth Factor A genetics
Endometrium diagnostic imaging
Follicular Phase
Infertility, Female blood
Leukemia Inhibitory Factor blood
Luteal Phase
Vascular Endothelial Growth Factor A metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6868
- Volume :
- 207
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 23099193
- Full Text :
- https://doi.org/10.1016/j.ajog.2012.09.028