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Synthesis of PEGylated gold nanostars and bipyramids for intracellular uptake.
- Source :
-
Nanotechnology [Nanotechnology] 2012 Nov 23; Vol. 23 (46), pp. 465602. Date of Electronic Publication: 2012 Oct 24. - Publication Year :
- 2012
-
Abstract
- A great number of works have focused their research on the synthesis, design and optical properties of gold nanoparticles for potential biological applications (bioimaging, biosensing). For this kind of application, sharp gold nanostructures appear to exhibit the more interesting features since their surface plasmon bands are very sensitive to the surrounding medium. In this paper, a complete study of PEGylated gold nanostars and PEGylated bipyramidal-like nanostructures is presented. The nanoparticles are prepared in high yield and their surfaces are covered with a biocompatible polymer. The photophysical properties of gold bipyramids and nanostars, in suspension, are correlated with the optical response of single and isolated objects. The resulting spectra of isolated gold nanoparticles are subsequently correlated to their geometrical structure by transmission electron microscopy. Finally, the PEGylated gold nanoparticles were incubated with melanoma B16-F10 cells. Dark-field microscopy showed that the biocompatible gold nanoparticles were easily internalized and most of them localized within the cells.
- Subjects :
- Animals
Cell Line, Tumor
Cetrimonium
Cetrimonium Compounds chemistry
Endocytosis
Gold pharmacokinetics
Histocytochemistry
Materials Testing
Mice
Nanostructures ultrastructure
Particle Size
Polyethylene Glycols chemistry
Quaternary Ammonium Compounds chemistry
Spectrophotometry, Ultraviolet
Surface-Active Agents chemistry
Gold chemistry
Metal Nanoparticles chemistry
Nanostructures chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1361-6528
- Volume :
- 23
- Issue :
- 46
- Database :
- MEDLINE
- Journal :
- Nanotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 23095344
- Full Text :
- https://doi.org/10.1088/0957-4484/23/46/465602