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Delayed development of specific thyroid hormone-regulated events in transthyretin null mice.
- Source :
-
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2013 Jan 01; Vol. 304 (1), pp. E23-31. Date of Electronic Publication: 2012 Oct 23. - Publication Year :
- 2013
-
Abstract
- Thyroid hormones (THs) are vital for normal postnatal development. Extracellular TH distributor proteins create an intravascular reservoir of THs. Transthyretin (TTR) is a TH distributor protein in the circulatory system and is the only TH distributor protein synthesized in the central nervous system. We investigated the phenotype of TTR null mice during development. Total and free 3',5',3,5-tetraiodo-L-thyronine (T(4)) and free 3',3,5-triiodo-L-thyronine (T(3)) in plasma were significantly reduced in 14-day-old (P14) TTR null mice. TTR null mice also displayed a delayed suckling-to-weaning transition, decreased muscle mass, delayed growth, and retarded longitudinal bone growth. In addition, ileums from postnatal day 0 (P0) TTR null mice displayed disordered architecture and contained fewer goblet cells than wild type. Protein concentrations in cerebrospinal fluid from P0 and P14 TTR null mice were higher than in age-matched wild-type mice. In contrast to the current literature based on analyses of adult TTR null mice, our results demonstrate that TTR has an important and nonredundant role in influencing the development of several organs.
- Subjects :
- Animals
Blood Chemical Analysis
Blood Glucose metabolism
Growth Disorders blood
Growth Disorders metabolism
Growth and Development physiology
Mice
Mice, Knockout
Organ Specificity drug effects
Organ Specificity genetics
Prealbumin metabolism
Prealbumin physiology
Thyroid Function Tests
Thyrotropin blood
Thyroxine blood
Triiodothyronine blood
Urea blood
Growth Disorders genetics
Growth and Development drug effects
Prealbumin genetics
Thyroid Hormones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1555
- Volume :
- 304
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 23092911
- Full Text :
- https://doi.org/10.1152/ajpendo.00216.2012