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Statin use and association with colorectal cancer survival and risk: case control study with prescription data linkage.
- Source :
-
BMC cancer [BMC Cancer] 2012 Oct 22; Vol. 12, pp. 487. Date of Electronic Publication: 2012 Oct 22. - Publication Year :
- 2012
-
Abstract
- Background: In Scotland colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer death. Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival.<br />Methods: Analysis was carried out on 309 cases and 294 controls from the Scottish Study of Colorectal Cancer (SOCCS). Cox's hazard and logistic regression models were applied to investigate the association between statin use and CRC risk and survival.<br />Results: In an adjusted logistic regression model, statins were found to show a statistically significant association for three of the four statin variables and were found to not show a statistically significant association with either all-cause or CRC-specific mortality (OR 0.49; 95%CI 0.49-1.36; p-value = 0.17 and OR 0.33; 95%CI 0.08-1.35; P-value = 0.12, respectively).<br />Conclusion: We did find a statistically significant association between statin intake and CRC risk but not statin intake and CRC-specific mortality. However, the study was insufficiently powered and larger scale studies may be advisable.
- Subjects :
- Case-Control Studies
Colorectal Neoplasms mortality
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors adverse effects
Logistic Models
Male
Middle Aged
Proportional Hazards Models
Risk
Scotland epidemiology
Colorectal Neoplasms epidemiology
Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 23088590
- Full Text :
- https://doi.org/10.1186/1471-2407-12-487