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A subunit vaccine against hydropericardium syndrome using adenovirus penton capsid protein.
- Source :
-
Vaccine [Vaccine] 2012 Nov 26; Vol. 30 (50), pp. 7153-6. Date of Electronic Publication: 2012 Oct 18. - Publication Year :
- 2012
-
Abstract
- Hydropericardium syndrome (HPS) is a disease of poultry that is caused by fowl adenovirus-4. Inactivated liver homogenate from diseased birds is still the choice of vaccine in some countries which disseminates numerous pathogens along with inactivated virus. Moreover incomplete attenuation or inactivation, reversion to virulence and the oncogenic potential/genetic instability of the adenoviruses have prevented their use in routine vaccines. To address this problem an effort is made to develop a subunit vaccine. For this purpose penton base protein of HPS virus was expressed in Escherichia coli and used as subunit vaccine in broilers. Immunogenicity of the recombinant penton base protein and challenge protection test against pathogenic virus demonstrated the ability of recombinant penton base protein to confer (90%) protection. Results suggest that the recombinant penton base protein is a candidate for subunit vaccine against HPS.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adenoviridae Infections prevention & control
Animals
Capsid Proteins administration & dosage
Escherichia coli genetics
Gene Expression
Pericarditis prevention & control
Poultry
Vaccines, Subunit administration & dosage
Vaccines, Subunit immunology
Vaccines, Synthetic administration & dosage
Vaccines, Synthetic immunology
Viral Vaccines administration & dosage
Adenoviridae Infections veterinary
Capsid Proteins immunology
Pericarditis veterinary
Poultry Diseases prevention & control
Viral Vaccines immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2518
- Volume :
- 30
- Issue :
- 50
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 23085359
- Full Text :
- https://doi.org/10.1016/j.vaccine.2012.10.013