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NSort/DB: an intranuclear compartment protein database.

NSort/DB: an intranuclear compartment protein database.

Authors :
Willadsen K
Mohamad N
Bodén M
Source :
Genomics, proteomics & bioinformatics [Genomics Proteomics Bioinformatics] 2012 Aug; Vol. 10 (4), pp. 226-9. Date of Electronic Publication: 2012 Jul 25.
Publication Year :
2012

Abstract

Distinct substructures within the nucleus are associated with a wide variety of important nuclear processes. Structures such as chromatin and nuclear pores have specific roles, while others such as Cajal bodies are more functionally varied. Understanding the roles of these membraneless intra-nuclear compartments requires extensive data sets covering nuclear and compartment-associated proteins. NSort/DB is a database providing access to intra- or sub-nuclear compartment associations for the mouse nuclear proteome. Based on resources ranging from large-scale curated data sets to detailed experiments, this data set provides a high-quality set of annotations of non-exclusive association of nuclear proteins with structures such as promyelocytic leukaemia bodies and chromatin. The database is searchable by protein identifier or compartment, and has a documented web service API. The search interface, web service and data download are all freely available online at http://www.nsort.org/db/. Availability of this data set will enable systematic analyses of the protein complements of nuclear compartments, improving our understanding of the diverse functional repertoire of these structures.<br /> (Copyright © 2012. Published by Elsevier Ltd.)

Details

Language :
English
ISSN :
2210-3244
Volume :
10
Issue :
4
Database :
MEDLINE
Journal :
Genomics, proteomics & bioinformatics
Publication Type :
Academic Journal
Accession number :
23084778
Full Text :
https://doi.org/10.1016/j.gpb.2012.07.001