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Effectiveness and tolerability of rufinamide in children and young adults with Lennox-Gastaut syndrome: a single center study in Korea.
- Source :
-
Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2013 Jul; Vol. 115 (7), pp. 926-9. Date of Electronic Publication: 2012 Oct 16. - Publication Year :
- 2013
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Abstract
- Purpose: Rufinamide is a novel antiepileptic drug (AED), which is known to be effective in the treatment of partial seizures and drop attacks in patients with Lennox-Gastaut syndrome (LGS). The aim of this study is to evaluate the efficacy and tolerability of rufinamide in those with LGS.<br />Methods: Patients with LGS who had received rufinamide adjunctive therapy were enrolled in this study. We retrospectively reviewed these patient's baseline clinical characteristics, and the reduction of seizure frequency and adverse events after the use of rufinamide.<br />Results: Twenty-three patients (15 males and 8 females, ages 4-22 years) were enrolled in the study. All the patients suffered from daily head drops and tonic seizures despite multiple antiepileptic drugs. After one month of rufinamide, one patient (4.3%) achieved freedom from seizures, ten (43.5%) achieved a ≥50% decrease in seizure frequency. After six months of rufinamide, eight patients (34.8%) maintained a satisfactory response (seizure free in one, and greater than 50% seizure reduction in seven). Adverse events were reported in six (26.0%) patients, which were somnolence in three, aggressive behavior in two, and aggravation of seizure in one patient.<br />Conclusions: Our results suggest that rufinamide is effective and safe in children and young adults with LGS.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Anticonvulsants adverse effects
Child
Child, Preschool
Electroencephalography
Female
Humans
Intellectual Disability psychology
Intellectual Disability surgery
Lennox Gastaut Syndrome
Male
Neurosurgical Procedures
Republic of Korea
Retrospective Studies
Seizures drug therapy
Seizures etiology
Spasms, Infantile psychology
Spasms, Infantile surgery
Treatment Outcome
Triazoles adverse effects
Young Adult
Anticonvulsants therapeutic use
Intellectual Disability drug therapy
Spasms, Infantile drug therapy
Triazoles therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6968
- Volume :
- 115
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Clinical neurology and neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- 23083943
- Full Text :
- https://doi.org/10.1016/j.clineuro.2012.09.021