Accuracy of whole-body FDG-PET and FDG-PET/CT in M staging of nasopharyngeal carcinoma: a systematic review and meta-analysis.

Authors :: Chang MC
Chen JH
Liang JA
Yang KT
Cheng KY
Kao CH
Source :: European journal of radiology [Eur J Radiol] 2013 Feb; Vol. 82 (2), pp. 366-73. Date of Electronic Publication: 2012 Oct 18.
Publication Year :: 2013
Abstract: Background: A meta-analysis was conducted to evaluate the accuracy of whole-body positron emission tomography (PET) or PET/CT in M staging of nasopharyngeal carcinoma (NPC).<br />Methods: Through a search of relevant English language studies from October 1996 to September 2011, pooled estimated sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, and summary receiver operating characteristic (SROC) curves of whole-body PET or PET/CT in M staging of NPC were calculated.<br />Results: Three PET and 5 PET/CT studies were identified. The pooled sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of FDG-PET or PET/CT were 0.83 (95% confidence interval [CI], 0.77-0.88), 0.97 (95% CI, 0.95-0.98), 23.38 (95% CI, 16.22-33.69), and 0.19 (95% CI, 0.13-0.25), respectively. The area under curve was 0.9764 and Q* index estimate was 0.9307 for FDG-PET or PET/CT.<br />Conclusion: Current evidence confirms the good diagnostic performance of the whole-body FDG-PET or PET/CT in M staging of NPC.<br /> (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Subjects :: Humans
Neoplasm Staging
Prevalence
Radiopharmaceuticals
Reproducibility of Results
Risk Factors
Sensitivity and Specificity
Fluorodeoxyglucose F18
Multimodal Imaging methods
Nasopharyngeal Neoplasms epidemiology
Nasopharyngeal Neoplasms pathology
Positron-Emission Tomography
Tomography, X-Ray Computed
Whole Body Imaging statistics & numerical data

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