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In vivo activity of an azole series of CCR2 antagonists.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Dec 01; Vol. 22 (23), pp. 7252-5. Date of Electronic Publication: 2012 Sep 23. - Publication Year :
- 2012
-
Abstract
- Optimisation of a series of biaryl sulphonamides resulted in the identification of compound 14 [corrected] which demonstrated dose-dependent and strain-specific inhibition of monocyte recruitment in a thioglycollate-induced peritonitis model of inflammation. [Formula: see text]. [corrected].<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Administration, Oral
Animals
Azoles chemical synthesis
Azoles pharmacokinetics
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System metabolism
Half-Life
Protein Binding
Rats
Receptors, CCR2 metabolism
Structure-Activity Relationship
Sulfonamides chemical synthesis
Sulfonamides pharmacokinetics
Azoles chemistry
Receptors, CCR2 antagonists & inhibitors
Sulfonamides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 22
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 23079519
- Full Text :
- https://doi.org/10.1016/j.bmcl.2012.09.020