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[Effect of heavy ion beam irradiation on serum interleukin-2 level in a hamster model bearing cheek pouch carcinoma].
- Source :
-
Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2012 Oct; Vol. 32 (10), pp. 1427-30. - Publication Year :
- 2012
-
Abstract
- Objective: To investigate the changes in serum interleukin-2 (IL-2) level in a hamster model bearing cheek pouch carcinoma after heavy ion beams irradiation.<br />Methods: The serum levels of IL-2 were detected using enzyme-linked immunosorbant assay in 40 hamsters bearing cheek pouch carcinoma before and after exposure to heavy ion beam irradiation, with 8 normal animals as control.<br />Results: Serum IL-2 level was 0.16∓0.01 in the tumor-bearing hamsters before the irradiation, lower than that in the control group. After heavy ion beams irradiation at 4, 6, 8, and 12 Gy, serum IL-2 levels in the tumor-bearing hamsters were 0.18∓0.04, 0.22∓0.05, 0.15∓0.03, and 0.13∓0.04, respectively, showing a peak level after irradiation at 6 Gy and an obvious decrease following irradiation at greater doses.<br />Conclusion: Heavy ion beam irradiation causes alterations in serum IL-2 level with a dose-effect relation between them in hamsters bearing cheek pouch carcinoma.
Details
- Language :
- Chinese
- ISSN :
- 1673-4254
- Volume :
- 32
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nan fang yi ke da xue xue bao = Journal of Southern Medical University
- Publication Type :
- Academic Journal
- Accession number :
- 23076177