Back to Search
Start Over
Bronchial hyperresponsiveness in patients with chronic congestive heart failure.
- Source :
-
Chest [Chest] 1990 Mar; Vol. 97 (3), pp. 534-8. - Publication Year :
- 1990
-
Abstract
- To investigate the relationship between pulmonary congestion and bronchial responsiveness, we measured bronchial responsiveness to acetylcholine in 51 patients with left heart disorders. The measurement of bronchial responsiveness was performed by inhaling doses of acetylcholine chloride (0.08 to 20 mg/ml) and calculating the PC20-FEV1. The median value for PC20-FEV1 was above 20 mg/ml in the subjects without history of congestive heart failure (n = 18), was 5.29 mg/ml in the subjects with clinical evidence of congestive heart failure in the past days (n = 18; p less than 0.01), and was 5.74 mg/ml in the subjects with clinical evidence of congestive heart failure at the time of study (n = 15; p less than 0.01). The hemodynamic variables by cardiac catheterization and the clinical symptoms were not correlated with the grade of bronchial responsiveness. These results suggest that the bronchial responsiveness was increased in most of the patients with chronic congestive heart failure. We concluded that continuous pulmonary congestion may contribute to the pathogenesis of bronchial hyperresponsiveness.
- Subjects :
- Acetylcholine
Adult
Aged
Blood Pressure physiology
Bronchial Provocation Tests
Cardiac Catheterization
Chronic Disease
Female
Forced Expiratory Volume physiology
Heart Rate physiology
Humans
Male
Middle Aged
Pulmonary Edema physiopathology
Pulmonary Wedge Pressure physiology
Spirometry
Bronchi physiopathology
Heart Failure physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0012-3692
- Volume :
- 97
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Chest
- Publication Type :
- Academic Journal
- Accession number :
- 2306955
- Full Text :
- https://doi.org/10.1378/chest.97.3.534