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Bronchial hyperresponsiveness in patients with chronic congestive heart failure.

Authors :
Sasaki F
Ishizaki T
Mifune J
Fujimura M
Nishioka S
Miyabo S
Source :
Chest [Chest] 1990 Mar; Vol. 97 (3), pp. 534-8.
Publication Year :
1990

Abstract

To investigate the relationship between pulmonary congestion and bronchial responsiveness, we measured bronchial responsiveness to acetylcholine in 51 patients with left heart disorders. The measurement of bronchial responsiveness was performed by inhaling doses of acetylcholine chloride (0.08 to 20 mg/ml) and calculating the PC20-FEV1. The median value for PC20-FEV1 was above 20 mg/ml in the subjects without history of congestive heart failure (n = 18), was 5.29 mg/ml in the subjects with clinical evidence of congestive heart failure in the past days (n = 18; p less than 0.01), and was 5.74 mg/ml in the subjects with clinical evidence of congestive heart failure at the time of study (n = 15; p less than 0.01). The hemodynamic variables by cardiac catheterization and the clinical symptoms were not correlated with the grade of bronchial responsiveness. These results suggest that the bronchial responsiveness was increased in most of the patients with chronic congestive heart failure. We concluded that continuous pulmonary congestion may contribute to the pathogenesis of bronchial hyperresponsiveness.

Details

Language :
English
ISSN :
0012-3692
Volume :
97
Issue :
3
Database :
MEDLINE
Journal :
Chest
Publication Type :
Academic Journal
Accession number :
2306955
Full Text :
https://doi.org/10.1378/chest.97.3.534