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Efficacy and safety of orally disintegrating tamsulosin tablets in Taiwanese patients with benign prostatic hyperplasia.
- Source :
-
The aging male : the official journal of the International Society for the Study of the Aging Male [Aging Male] 2012 Dec; Vol. 15 (4), pp. 246-52. Date of Electronic Publication: 2012 Oct 15. - Publication Year :
- 2012
-
Abstract
- Objectives: Tamsulosin is an alpha-1 adrenoceptor antagonist applied in treating lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH). This study aimed to evaluate safety, efficacy and acceptance of newly formulated orally disintegrating tamsulosin tablets in Taiwanese patients with LUTS/BPH.<br />Methods: This single center, non-comparative, observational study enrolled 45 male patients over age 50 years. All patients received 0.2 mg tamsulosin orally disintegrating tablets daily and were evaluated at weeks 0, 4, 8, 12 of the 12-week treatment period. Tamsulosin efficacy was evaluated by International Prostate Symptom Score (I-PSS) with 7 questions on urinary symptoms and one disease-specific quality-of-life question, with scores ranging from 0 (no symptoms) to 35 (highly symptomatic). Maximum flow rate (ml/s), voided volume (ml), flow time (s), and mean flow rate (ml/s) were measured. Danish prostatic symptom sexual function scale rated severity and associated concerns of erection quality, ejaculatory function and pain/discomfort were also assessed.<br />Results: Patients' mean ± SD age was 62.47 ± 7.77 (range: 50-89) and mean ± SD I-PSS was 13.98 ± 5.50. Statistically significant changes from baseline were found in post-test I-PSS and quality of life (both P < 0.001). Mean ± SD I-PSS decreased from 14.30 ± 9.34 to 6.73 ± 0.88 at patients' final visit. Statistically significant increases in mean maximum flow rate and mean flow rate were found over 12-week study period (P < 0.05). No adverse events were reported. No significant differences were found in pulse, SBP/DBP or sexual function.<br />Conclusion: Orally disintegrating tamsulosin tablets demonstrate acceptable safety and efficacy for acceptance and well tolerance by Taiwanese LUTS/BPH patients.
- Subjects :
- Administration, Oral
Adrenergic alpha-1 Receptor Antagonists adverse effects
Aged
Aged, 80 and over
Humans
Lower Urinary Tract Symptoms drug therapy
Male
Middle Aged
Outcome Assessment, Health Care
Sulfonamides adverse effects
Tablets
Taiwan
Tamsulosin
Urodynamics drug effects
Adrenergic alpha-1 Receptor Antagonists administration & dosage
Prostatic Hyperplasia drug therapy
Sulfonamides administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1473-0790
- Volume :
- 15
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The aging male : the official journal of the International Society for the Study of the Aging Male
- Publication Type :
- Academic Journal
- Accession number :
- 23067262
- Full Text :
- https://doi.org/10.3109/13685538.2012.724741