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Origin of celiac disease: how old are predisposing haplotypes?
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2012 Oct 07; Vol. 18 (37), pp. 5300-4. - Publication Year :
- 2012
-
Abstract
- We recently presented the case of a first century AD young woman, found in the archaeological site of Cosa, showing clinical signs of malnutrition, such as short height, osteoporosis, dental enamel hypoplasia and cribra orbitalia, indirect sign of anemia, all strongly suggestive for celiac disease (CD). However, whether these findings were actually associated to CD was not shown based on genetic parameters. To investigate her human leukocyte antigen (HLA) class II polymorphism, we extracted DNA from a bone sample and a tooth and genotyped HLA using three HLA-tagging single nucleotide polymorphisms for DQ8, DQ2.2 and DQ2.5, specifically associated to CD. She displayed HLA DQ 2.5, the haplotype associated to the highest risk of CD. This is the first report showing the presence of a HLA haplotype compatible for CD in archaeological specimens.
- Subjects :
- Archaeology methods
DNA Primers genetics
DNA, Mitochondrial genetics
Female
Genotype
HLA Antigens metabolism
HLA-DQ Antigens genetics
Humans
Italy
Malabsorption Syndromes genetics
Polymorphism, Genetic
Risk
Celiac Disease diagnosis
Celiac Disease genetics
Genetic Predisposition to Disease
Haplotypes
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 18
- Issue :
- 37
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 23066327
- Full Text :
- https://doi.org/10.3748/wjg.v18.i37.5300