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Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2012 Oct 14; Vol. 12, pp. 258. Date of Electronic Publication: 2012 Oct 14. - Publication Year :
- 2012
-
Abstract
- Background: A Giardia outbreak was associated with development of post-infectious functional gastrointestinal disorders (PI-FGID) and chronic fatigue syndrome (PI-CFS). Markers of immune dysfunction have given conflicting results in CFS and FGID patient populations. The aim of this study was to evaluate a wide selection of markers of immune dysfunction in these two co-occurring post-infectious syndromes.<br />Methods: 48 patients, reporting chronic fatigue in a questionnaire study, were clinically evaluated five years after the outbreak and grouped according to Fukuda criteria for CFS (n=19) and idiopathic chronic fatigue (n=5) and Rome II criteria for FGIDs (n=54). 22 Giardia exposed non-fatigued individuals and 10 healthy unexposed individuals were recruited as controls. Peripheral blood lymphocyte subsets were analyzed by flow cytometry.<br />Results: In peripheral blood we found significantly higher CD8 T-cell levels in PI-FGID, and significantly lower NK-cell levels in PI-CFS patients. Severity of abdominal and fatigue symptoms correlated negatively with NK-cell levels. A tendency towards lower T-cell CD26 expression in FGID was seen.<br />Conclusion: Patients with PI-CFS and/or PI-FGID 5 years after Giardia lamblia infection showed alterations in NK-cell and CD8-cell populations suggesting a possible immunological abnormality in these conditions. We found no significant changes in other markers examined in this well-defined group of PI-CFS and PI-FGID elicited by a gastrointestinal infection. Controlling for co-morbid conditions is important in evaluation of CFS-biomarkers.
- Subjects :
- Adult
Aged
CD4-Positive T-Lymphocytes metabolism
CD8-Positive T-Lymphocytes metabolism
Fatigue Syndrome, Chronic etiology
Female
Gastrointestinal Diseases etiology
Humans
Male
Middle Aged
Fatigue Syndrome, Chronic immunology
Gastrointestinal Diseases immunology
Giardiasis complications
Immunophenotyping methods
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 23061432
- Full Text :
- https://doi.org/10.1186/1471-2334-12-258