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Aflatoxin-induced biochemical changes in liver of mice and its mitigation by black tea extract.
- Source :
-
Acta poloniae pharmaceutica [Acta Pol Pharm] 2012 Sep-Oct; Vol. 69 (5), pp. 851-7. - Publication Year :
- 2012
-
Abstract
- Aflatoxin belongs to the class of naturally occurring mycotoxins, food contaminants having potent carcinogenicity. We have evaluated the ameliorative role of black tea extract on aflatoxin-induced biochemical changes in the liver of albino male mice. Adult male mice were orally administered with 750 and 1500 pg of aflatoxin in 0.2 mL olive oil/kg b.w./day for 30 days. Oral administration of aflatoxin caused, as compared with controls, significant, dose-dependent reduction in DNA, RNA, protein and glycogen contents; however, cholesterol content and phsphorylase activity were significantly increased. Black tea is one of the most potent antioxidants containing numerous bioactive phytonurtients having therapeutic applications. Aflatoxin-induced changes in the liver of mice were significantly ameliorated on co-treatment of black tea extract (2% infusion in water).
Details
- Language :
- English
- ISSN :
- 0001-6837
- Volume :
- 69
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Acta poloniae pharmaceutica
- Publication Type :
- Academic Journal
- Accession number :
- 23061280