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Prognostic factors of 2-year outcomes of patients with comorbid bipolar disorder or depression with alcohol dependence: importance of early abstinence.
- Source :
-
Alcohol and alcoholism (Oxford, Oxfordshire) [Alcohol Alcohol] 2013 Jan-Feb; Vol. 48 (1), pp. 93-8. Date of Electronic Publication: 2012 Oct 11. - Publication Year :
- 2013
-
Abstract
- Aims: To investigate the prognostic factors that determine 2-year outcomes in a group of alcohol-dependent patients with depression or bipolar disorder who were treated in an intensive 4-week inpatient programme.<br />Methods: This was a longitudinal study of an inpatient treatment cohort of dual affective disorder and alcohol-dependent patients, in Dublin, Ireland. Measurements included baseline demographics with follow-up measurements at discharge, 3 months, 6 months and 2 years after treatment, including alcohol consumption, depression, mania/elation, anxiety, craving, drug use and sample blood tests. Factor and regression analysis of multiple variables was carried out to predict outcomes.<br />Results: A total of 189 participants with alcohol dependence and comorbid depression (n = 101) or bipolar disorder (n = 88) were followed over 2 years after discharge from treatment. Retention rate was 76% over 2 years. Early abstinence (at 6 months) predicted better abstinence overall at 2 years; and bipolar alcoholics had a better outcome in drinks per drinking day than depressed alcoholics at 2 years. Younger participants (age 18-30 years) did relatively worse than middle-age (30-50 years) and older (51 + years) participants in measures of abstinence and number of drinks per drinking day at 2 years; and females did better than males in number of drinks per drinking day at 2 years.<br />Conclusion: Dual diagnosis of alcohol dependence and depression or bipolar disorder may be treated together with intensive intervention and follow-up, and various prognostic factors including early abstinence emerge over time that influence outcomes over 2 years.
- Subjects :
- Adolescent
Adult
Aged
Alcoholism diagnosis
Alcoholism therapy
Bipolar Disorder diagnosis
Bipolar Disorder therapy
Cohort Studies
Comorbidity
Depression diagnosis
Depression therapy
Diagnosis, Dual (Psychiatry)
Female
Follow-Up Studies
Humans
Ireland epidemiology
Longitudinal Studies
Male
Middle Aged
Prognosis
Time Factors
Treatment Outcome
Young Adult
Alcoholism epidemiology
Bipolar Disorder epidemiology
Depression epidemiology
Temperance trends
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3502
- Volume :
- 48
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Alcohol and alcoholism (Oxford, Oxfordshire)
- Publication Type :
- Academic Journal
- Accession number :
- 23059424
- Full Text :
- https://doi.org/10.1093/alcalc/ags112