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Prediction of axillary lymph node status in male breast carcinoma.
- Source :
-
Annals of oncology : official journal of the European Society for Medical Oncology [Ann Oncol] 2013 Feb; Vol. 24 (2), pp. 370-376. Date of Electronic Publication: 2012 Oct 09. - Publication Year :
- 2013
-
Abstract
- Background: To evaluate whether predictive factors of axillary lymph node metastasis in female breast cancer (BC) are similar in male BC.<br />Patients and Methods: From January 1994 to May 2011, we recorded 80 non-metastatic male BC treated at Institut Curie (IC). We analysed the calibration and discrimination performance of two nomograms [IC, Memorian Sloan-Kettering Cancer Center (MSKCC)] originally designed to predict axillary lymph node metastases in female BC.<br />Results: About 55% and 24% of the tumours were pT1 and pT4, respectively. Nearly 46% demonstrated axillary lymph node metastasis. About 99% were oestrogen receptor positive and 94% HER2 negative. Lymph node status was the only significant prognostic factor of overall survival (P = 0.012). The area under curve (AUC) of IC and MSKCC nomograms were 0.66 (95% CI 0.54-0.79) and 0.64 (95% CI 0.52-0.76), respectively. The calibration of these two models was inadequate.<br />Conclusions: Multi-variate models designed to predict axillary lymph node metastases for female BC were not effective in our male BC series. Our results may be explained by (i) small sample size (ii) different biological determinants influencing axillary metastasis in male BC compared with female BC.
- Subjects :
- Adult
Aged
Aged, 80 and over
Axilla
Breast Neoplasms, Male mortality
Breast Neoplasms, Male surgery
Female
Humans
Lymph Node Excision
Lymph Nodes pathology
Lymph Nodes surgery
Male
Middle Aged
Nomograms
Prognosis
Retrospective Studies
Sentinel Lymph Node Biopsy
Breast Neoplasms, Male pathology
Lymphatic Metastasis
Receptor, ErbB-2 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1569-8041
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Annals of oncology : official journal of the European Society for Medical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 23051951
- Full Text :
- https://doi.org/10.1093/annonc/mds283