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Synthesis of oxindolyl pyrazolines and 3-amino oxindole building blocks via a nitrile imine [3 + 2] cycloaddition strategy.
- Source :
-
Organic letters [Org Lett] 2012 Oct 19; Vol. 14 (20), pp. 5266-9. Date of Electronic Publication: 2012 Oct 10. - Publication Year :
- 2012
-
Abstract
- The [3 + 2] dipolar cycloaddition reaction of nitrile imines with 3-alkylidene oxindoles is described. The pyrazoline spiroadducts were obtained in high yields and with excellent regio- and diastereoselectivities. These spirocyclic intermediates have been elaborated to synthetically versatile 3-amino oxindole building blocks such as β-amino nitrile, 1,3-diamine, and pyrrolo[2,3-b]indoline derivatives.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 14
- Issue :
- 20
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 23050551
- Full Text :
- https://doi.org/10.1021/ol302425h