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Evaluation of the prognostic meaning of C-reactive protein (CRP) in children and adolescents with classical Hodgkin's lymphoma (HL).
- Source :
-
Klinische Padiatrie [Klin Padiatr] 2012 Oct; Vol. 224 (6), pp. 377-81. Date of Electronic Publication: 2012 Oct 09. - Publication Year :
- 2012
-
Abstract
- Background: In adult cancer patients the negative predictive value of elevated CRP levels has been described for several malignancies. Only few studies have analyzed the prognostic role of CRP in children and adolescents with classical HL. In these studies elevated CRP levels correlate with the presence of classical risk factors and adverse outcome.<br />Patients and Methods: The prognostic role of CRP for patients with classical HL admitted to the GPOH-HD-2002 study was analyzed retrospectively.<br />Results: CRP levels were documented for 369 of 573 patients. Significant (p<0.05) increased median CRP levels were found in the presence of B-Symptoms (25.7 vs. 5.1 mg/l), extranodal involvement (21.5 vs. 7.5 mg/l), elevated erythrocyte sedimentation rate (ESR, 13.0 vs. 1.0 mg/l) and stage III/IV disease (15.5 vs. 5.3 mg/l). 83.9% of patients with elevated and 45.8% of patients with normal CRP had an ESR >30 mm/h.<br />Conclusion: Elevated CRP levels were associated with classical risk factors of HL. CRP and ESR may reflect different biological processes. CRP was prognostic within early stage TG-1 patients treated with reduced treatment, but not within advanced stage TG-2+3.<br /> (© Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Adolescent
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Blood Sedimentation
Child
Cohort Studies
Drug Administration Schedule
Female
Follow-Up Studies
Germany
Hodgkin Disease mortality
Hodgkin Disease pathology
Hodgkin Disease therapy
Humans
Male
Neoplasm Staging
Prognosis
Radiotherapy, Adjuvant
Retrospective Studies
Risk Factors
Survival Rate
Biomarkers, Tumor blood
C-Reactive Protein metabolism
Hodgkin Disease blood
Hodgkin Disease diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1439-3824
- Volume :
- 224
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Klinische Padiatrie
- Publication Type :
- Academic Journal
- Accession number :
- 23047832
- Full Text :
- https://doi.org/10.1055/s-0032-1323824