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Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned (23)Na/(1)H resonator systems.
- Source :
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Physics in medicine and biology [Phys Med Biol] 2012 Nov 07; Vol. 57 (21), pp. 6929-46. Date of Electronic Publication: 2012 Oct 09. - Publication Year :
- 2012
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Abstract
- A double-tuned ²³Na/¹H resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. ¹H-diffusion-, (¹H perfusion, ¹H T₂-, ¹H arterial blood flow- and ²³Na spin density-weighted images were then acquired at three time points in a rodent stroke model: (I) during 90 min artery occlusion, (II) directly after arterial reperfusion and (III) one day after arterial reperfusion. Normal ²³Na was detected in hypoperfused stroke tissue which exhibited a low ¹H apparent diffusion coefficient (ADC) and no changes in ¹H T₂ relaxation time during transient ischemia, while ²³Na increased and ADC values recovered to normal values directly after arterial reperfusion. For the first time, a similar imaging protocol was set-up on a clinical 3T MRI site in conjunction with a commercial double-tuned ¹H/²³Na birdcage resonator avoiding a time-consuming exchange of resonators or MRI systems. Multinuclear ²³Na/¹H MRI data sets were obtained from one stroke patient during both the acute and non-acute stroke phases with an aquisition time of 22 min. The lesion exhibiting low ADC was found to be larger compared to the lesion with high ²³Na at 9 h after symptom onset. It is hoped that the presented pilot data demonstrate that fast multinuclear ²³Na/¹H MRI preclinical and clinical protocols can enable a better understanding of how temporal and regional MRI parameter changes link to pathophysiological variations in ischemic stroke tissue.
- Subjects :
- Animals
Cerebrovascular Circulation
Hydrogen
Infarction, Middle Cerebral Artery physiopathology
Ischemic Attack, Transient physiopathology
Male
Rats
Rats, Wistar
Sodium Isotopes
Infarction, Middle Cerebral Artery diagnosis
Ischemic Attack, Transient diagnosis
Magnetic Resonance Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1361-6560
- Volume :
- 57
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Physics in medicine and biology
- Publication Type :
- Academic Journal
- Accession number :
- 23044614
- Full Text :
- https://doi.org/10.1088/0031-9155/57/21/6929