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Cytotoxic drug-induced fever: a report on procarbazine-induced hyperpyrexia.
- Source :
-
Medical and pediatric oncology [Med Pediatr Oncol] 1990; Vol. 18 (2), pp. 173-5. - Publication Year :
- 1990
-
Abstract
- A case of hyperpyrexia induced by procarbazine in a child with Hodgkin's disease, neurofibromatosis, and pectus excavatum deformity is presented. After the diagnosis of stage IIIS Hodgkin's disease, combined COPP chemotherapy was initiated. One week later she presented with high fever. After a diagnosis of infection was made, chemotherapy was stopped and antibiotics were given. Nearly the same picture recurred three times after reinstituting chemotherapy. On the fourth occasion, the patient had to be hospitalized because of hyperpyrexia and arrhythmia. There was no obvious reason for fever, and cytotoxic-induced fever was considered. The drugs were given one at a time. When a test dose (10 mg) of procarbazine was given, she developed a high fever with severe nausea and vomiting. The reaction was controlled by antihistaminics and steroids. To our knowledge this is the second report on hyperpyrexia due to procarbazine administration.
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols adverse effects
Child
Cyclophosphamide administration & dosage
Diagnosis, Differential
Female
Hodgkin Disease drug therapy
Humans
Prednisone administration & dosage
Procarbazine administration & dosage
Vincristine administration & dosage
Fever chemically induced
Procarbazine adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0098-1532
- Volume :
- 18
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Medical and pediatric oncology
- Publication Type :
- Academic Journal
- Accession number :
- 2304425
- Full Text :
- https://doi.org/10.1002/mpo.2950180217