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Gastrointestinal stromal tumour of the duodenum: single institution experience.
- Source :
-
HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2012 Nov; Vol. 14 (11), pp. 772-6. Date of Electronic Publication: 2012 Aug 17. - Publication Year :
- 2012
-
Abstract
- Background: Primary gastrointestinal stromal tumours (GISTs) of the duodenum are rare. The aim of this study was to review the surgical management of GISTs in this anatomically complex region.<br />Methods: Retrospective review from January 1999 to August 2011 of patients with primary GISTs of the duodenum.<br />Results: Forty-one patients underwent resection of duodenal GISTs. All operations were performed with intent to cure with negative margins of resection. The most common location of origin was the second portion of the duodenum. Local excision (n= 19), segmental resection with primary anastomosis (n= 11) and a pancreatoduodenectomy (n= 11) were performed. Two patients underwent an ampullectomy with local excision. Peri-operative mortality and overall morbidity were 0 and 12, respectively. Patients with high-risk GISTs (P= 0.008) and those who underwent a pancreatoduodenectomy (P= 0.021) were at a greater risk for morbidity. The median follow-up was 18 months. Eight patients developed recurrence. High-risk GISTs and neoplasms with ulceration had the greatest risk for recurrence (P= 0.017, P= 0.029 respectively). The actuarial 3- and 5-year survivals were 85% and 74%, respectively.<br />Conclusion: The choice and type of resection depends on the proximity to the ampulla of Vater, involvement of adjacent organs and the ability to obtain negative margins. The morbidity depends on the type of procedure for GIST.<br /> (© 2012 International Hepato-Pancreato-Biliary Association.)
- Subjects :
- Adult
Aged
Ampulla of Vater pathology
Ampulla of Vater surgery
Anastomosis, Surgical
Duodenal Neoplasms mortality
Duodenal Neoplasms pathology
Female
Gastrointestinal Stromal Tumors mortality
Gastrointestinal Stromal Tumors secondary
Humans
Kaplan-Meier Estimate
Logistic Models
Male
Middle Aged
Minnesota
Neoplasm Recurrence, Local
Odds Ratio
Pancreaticoduodenectomy
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Risk Factors
Sphincterotomy, Transduodenal
Time Factors
Treatment Outcome
Digestive System Surgical Procedures adverse effects
Digestive System Surgical Procedures mortality
Duodenal Neoplasms surgery
Gastrointestinal Stromal Tumors surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2574
- Volume :
- 14
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- HPB : the official journal of the International Hepato Pancreato Biliary Association
- Publication Type :
- Academic Journal
- Accession number :
- 23043666
- Full Text :
- https://doi.org/10.1111/j.1477-2574.2012.00535.x