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Aldosterone and angiotensin: Role in diabetes and cardiovascular diseases.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2012 Dec 15; Vol. 697 (1-3), pp. 1-12. Date of Electronic Publication: 2012 Oct 04. - Publication Year :
- 2012
-
Abstract
- The present review shall familiarize the readers with the role of renin-angiotensin aldosterone system (RAAS), which regulates blood pressure, electrolyte and fluid homeostasis. The local RAAS operates in an autocrine, paracrine and/or intracrine manner and exhibits multiple physiological effects at the cellular level. In addition to local RAAS, there exists a complete pancreatic RAAS which has multi-facet role in diabetes and cardiovascular diseases. Aldosterone is known to mediate hyperinsulinemia, hypertension, cardiac failure and myocardial fibrosis while angiotensin II mediates diabetes, endothelial dysfunction, vascular inflammation, hypertrophy and remodeling. As the understanding of this biology of RAAS increases, it serves to exploit this for the pharmacotherapy of diabetes and cardiovascular diseases.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Autocrine Communication
Blood Pressure
Cardiovascular Diseases physiopathology
Diabetes Mellitus physiopathology
Humans
Paracrine Communication
Signal Transduction
Water-Electrolyte Balance
Aldosterone metabolism
Angiotensin II metabolism
Cardiovascular Diseases metabolism
Diabetes Mellitus metabolism
Renin-Angiotensin System
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0712
- Volume :
- 697
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 23041273
- Full Text :
- https://doi.org/10.1016/j.ejphar.2012.09.034