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Vasoactive substances in subchondral bone of the dog knee.
- Source :
-
Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 1990 Mar; Vol. 8 (2), pp. 205-12. - Publication Year :
- 1990
-
Abstract
- The purpose of the present study was to investigate regulatory mechanisms for subchondral bone blood flow. A model including elevation of joint cavity pressure in the immature dog knee was applied. The role of prostaglandins in bone blood flow regulation was indirectly examined by indomethacin blockade. In six puppies, both venous tamponade of the joint cavity [50% of the mean arterial blood pressure (MAP)] and arterial tamponade (150% of MAP) resulted in a significant increase in the intraosseous pressure of the distal femoral epiphyses (p less than 0.05). During venous tamponade no changes were registered in pO2, pCO2, pH, potassium, and lactate in blood withdrawn from the distal femoral epiphyses. Arterial tamponade resulted in hypoxia, a decrease in pH, and increased lactate. Inhibition of the prostaglandin synthesis did not alter this response pattern. Thus, the present study suggests the presence of a regulatory mechanism for subchondral bone blood flow since venous tamponade did not significantly alter intraosseous gas tensions, pH, lactate, or potassium in spite of elevated venous outlet resistance. The study does not allow any conclusion as to the exact nature of the regulatory mechanism, but local metabolic regulation is likely to be involved as indicated by accumulation of vasoactive substances at higher tamponade levels. Prostaglandins are probably of minor importance in this regulation.
- Subjects :
- Animals
Blood Pressure drug effects
Blood Pressure physiology
Bone and Bones blood supply
Bone and Bones physiology
Dogs
Knee Joint blood supply
Knee Joint physiology
Lactates blood
Potassium blood
Prostaglandins metabolism
Regional Blood Flow drug effects
Regional Blood Flow physiology
Bone and Bones drug effects
Knee Joint drug effects
Vasoconstrictor Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0736-0266
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of orthopaedic research : official publication of the Orthopaedic Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 2303953
- Full Text :
- https://doi.org/10.1002/jor.1100080208