Back to Search
Start Over
Combined effects of storage and processing on the bioactive compounds and pro-apoptotic properties of color-fleshed potatoes in human colon cancer cells.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2012 Nov 07; Vol. 60 (44), pp. 11088-96. Date of Electronic Publication: 2012 Oct 26. - Publication Year :
- 2012
-
Abstract
- Potatoes can be stored for up to 1 year before being processed and consumed. The objective of this study was to determine the extent to which fresh and stored color-fleshed potatoes retain their anticancer properties after baking and chipping compared with unprocessed potatoes. We utilized white-, yellow-, and purple-fleshed potato clones and tested their phenolic and anthocyanin content, antioxidant activity, metabolite profile, and antiproliferative and pro-apoptotic properties. When compared with unprocessed samples, baking or chipping led to significant losses in the phenolic and anthocyanin content and antioxidant activity of the potatoes. However, with storage, total phenolic and anthocyanin content and antioxidant activity increased in baked samples while in the chipped samples they remained constant. Ethanolic extracts of baked and chipped samples suppressed proliferation and elevated apoptosis (p < 0.05) in HCT-116 (p53 wild-type; ras mutated) and HT-29 (p53 mutated; ras wild-type) human colon cancer cell lines. Antiproliferative and pro-apoptotic properties of baked potatoes were similar to that of fresh potatoes, while chipping caused a significant suppression. Phenolic content and antioxidant activity of purple-fleshed potatoes, after baking, were comparable with those of anthocyanin-rich berries. Hence, purple-fleshed potatoes can be a healthier choice for consumers as they possess greater levels of bioactive compounds and anticancer properties even after processing as compared with their white- and yellow-fleshed counterparts.
- Subjects :
- Anthocyanins administration & dosage
Anthocyanins pharmacology
Antioxidants administration & dosage
Antioxidants pharmacology
Cell Line, Tumor
Cell Proliferation
Chromatography, Liquid
Colonic Neoplasms metabolism
Humans
Mass Spectrometry
Phenols analysis
Phenols pharmacology
Apoptosis
Colonic Neoplasms pathology
Food Handling
Solanum tuberosum chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 60
- Issue :
- 44
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 23039105
- Full Text :
- https://doi.org/10.1021/jf303528p