Back to Search
Start Over
Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population.
- Source :
-
Translational psychiatry [Transl Psychiatry] 2012 Oct 02; Vol. 2, pp. e164. Date of Electronic Publication: 2012 Oct 02. - Publication Year :
- 2012
-
Abstract
- The Mediterranean diet (MeDi), due to its correlation with a low morbidity and mortality for many chronic diseases, has been widely recognised as a healthy eating model. We aimed to investigate, in a cross-sectional study, the association between adherence to a MeDi and risk for Alzheimer's disease (AD) and mild cognitive impairment (MCI) in a large, elderly, Australian cohort. Subjects in the Australian Imaging, Biomarkers and Lifestyle Study of Ageing cohort (723 healthy controls (HC), 98 MCI and 149 AD participants) completed the Cancer Council of Victoria Food Frequency Questionnaire. Adherence to the MeDi (0- to 9-point scale with higher scores indicating higher adherence) was the main predictor of AD and MCI status in multinominal logistic regression models that were adjusted for cohort age, sex, country of birth, education, apolipoprotein E genotype, total caloric intake, current smoking status, body mass index, history of diabetes, hypertension, angina, heart attack and stroke. There was a significant difference in adherence to the MeDi between HC and AD subjects (P < 0.001), and in adherence between HC and MCI subjects (P < 0.05). MeDi is associated with change in Mini-Mental State Examination score over an 18-month time period (P < 0.05) in HCs. We conclude that in this Australian cohort, AD and MCI participants had a lower adherence to the MeDi than HC participants.
- Subjects :
- Aged
Alzheimer Disease prevention & control
Australia epidemiology
Cognitive Dysfunction epidemiology
Cognitive Dysfunction prevention & control
Cohort Studies
Cross-Sectional Studies
Female
Follow-Up Studies
Geriatric Assessment methods
Geriatric Assessment statistics & numerical data
Humans
Male
Neuropsychological Tests statistics & numerical data
Risk Factors
Surveys and Questionnaires
Alzheimer Disease epidemiology
Diet, Mediterranean statistics & numerical data
Patient Compliance statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 2158-3188
- Volume :
- 2
- Database :
- MEDLINE
- Journal :
- Translational psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 23032941
- Full Text :
- https://doi.org/10.1038/tp.2012.91