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Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers.
- Source :
-
AIDS (London, England) [AIDS] 2012 Nov 28; Vol. 26 (18), pp. 2409-12. - Publication Year :
- 2012
-
Abstract
- HIV-1 elite controllers spontaneously maintain suppressed levels of viremia, but exhibit significant immune activation. We investigated coronary atherosclerosis by coronary computed tomography angiography (CTA) in elite controllers, nonelite controller, chronically HIV-1 infected, antiretroviral therapy (ART)-treated patients with undetectable viral load ('chronic HIV'), and HIV-negative controls. Prevalence of atherosclerosis (78 vs. 42%, P < 0.05) and markers of immune activation were increased in elite controllers compared with HIV-negative controls. sCD163, a monocyte activation marker, was increased in elite controllers compared with chronic HIV-1 (P < 0.05) and compared with HIV-negative controls (P < 0.05). These data suggest a significant degree of coronary atherosclerosis and monocyte activation among elite controllers.
- Subjects :
- Angiography
CD4 Lymphocyte Count
Calcinosis physiopathology
Coronary Artery Disease diagnostic imaging
Coronary Artery Disease physiopathology
Disease Progression
Female
HIV Infections diagnostic imaging
HIV Infections physiopathology
Humans
Male
Middle Aged
Prevalence
Viral Load immunology
Calcinosis diagnostic imaging
Coronary Artery Disease immunology
HIV Infections immunology
HIV-1 immunology
Lymphocyte Activation immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 26
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 23032411
- Full Text :
- https://doi.org/10.1097/QAD.0b013e32835a9950