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The complex regulation of TGF-β in cardiovascular disease.
- Source :
-
Vascular health and risk management [Vasc Health Risk Manag] 2012; Vol. 8, pp. 533-9. Date of Electronic Publication: 2012 Sep 13. - Publication Year :
- 2012
-
Abstract
- Transforming growth factor β (TGF-β1) is a pleiotropic cytokine with many and complex effects in cell and tissue physiology. This is made possible by a very complex and interwoven signaling system, whose regulation continues to be the focus of a growing line of research. This complex regulation translates to a key role in cardiovascular physiology, hemostasis, and the blood-vessel interface. In accordance with this, the TGF-β1 pathway appears to be deregulated in related disorders, such as atherosclerotic vascular disease and myeloproliferative syndromes. It is expected that the growing amount of experimental and clinical research will yield medical advances in the applications of knowledge of the TGF-β1 pathway to diagnosis and therapeutics.
- Subjects :
- Animals
Cardiovascular Diseases genetics
Cardiovascular Diseases pathology
Cardiovascular System pathology
Gene Expression Regulation
Humans
Receptors, Transforming Growth Factor beta metabolism
Signal Transduction
Transforming Growth Factor beta1 genetics
Cardiovascular Diseases metabolism
Cardiovascular System metabolism
Transforming Growth Factor beta1 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2048
- Volume :
- 8
- Database :
- MEDLINE
- Journal :
- Vascular health and risk management
- Publication Type :
- Academic Journal
- Accession number :
- 23028232
- Full Text :
- https://doi.org/10.2147/VHRM.S28041