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Testing the efficacy of quercetin in mitigating bisphenol A toxicity in liver and kidney of mice.
- Source :
-
Toxicology and industrial health [Toxicol Ind Health] 2014 Aug; Vol. 30 (7), pp. 581-97. Date of Electronic Publication: 2012 Sep 28. - Publication Year :
- 2014
-
Abstract
- Quercetin (3,5,7,3',4'-pentahydroxy flavone) is a potent antioxidant found in various fruits and vegetables. The present investigation was an attempt to evaluate the mitigatory effect of quercetin on the damage caused by bisphenol A (BPA; 2,2-bis (4-hydroxyphenyl) propane), a well-known xenoestrogen, on liver and kidney of mice. Swiss strain adult male albino mice were orally administered with 120 and 240 mg/kg body weight (bw)/day BPA with or without quercetin (60 mg/kg bw/day) for 30 days. On the completion of the treatment period, animals were killed; organs were isolated and used for the study. Results revealed that oral administration of BPA for 30 days caused significant and dose-dependent decrease in body weight. Absolute and relative organ weights, total lipid and cholesterol contents were significantly increased in liver and kidney of mice when compared with vehicle control. BPA treatment also caused, when compared with vehicle control, a statistically significant reductions in the activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione-S-transferase as well as in glutathione and total ascorbic acid contents; however, significant increase was found in malondialdehyde (MDA) levels. Histopathological studies revealed hepatocellular necrosis, cytoplasmic vacuolization and decrease in hepatocellular compactness in liver as well as distortion of the tubules, increased vacuolization, necrosis and disorganization of glomerulus in the kidney of BPA-treated mice. All these effects were dose-dependent. Co-treatment with quercetin (60 mg/kg bw) and BPA (low dose and high dose) alleviates the changes in body weight, as well as absolute and relative organ weights of mice. It also ameliorates the oxidative stress created by BPA by lowering MDA levels and by increasing enzymatic and nonenzymatic antioxidants as well as it brings back the normal histoarchitecture of liver and kidney of mice. The present results revealed that graded doses of BPA caused oxidative damage in liver and kidney of mice, which is mitigated by quercetin.<br /> (© The Author(s) 2012.)
- Subjects :
- Animals
Benzhydryl Compounds antagonists & inhibitors
Body Weight drug effects
Catalase analysis
Dose-Response Relationship, Drug
Glutathione Peroxidase analysis
Kidney chemistry
Liver chemistry
Male
Malondialdehyde analysis
Mice
Organ Size drug effects
Phenols antagonists & inhibitors
Superoxide Dismutase analysis
Antioxidants pharmacology
Benzhydryl Compounds toxicity
Kidney drug effects
Liver drug effects
Phenols toxicity
Quercetin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0393
- Volume :
- 30
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Toxicology and industrial health
- Publication Type :
- Academic Journal
- Accession number :
- 23024108
- Full Text :
- https://doi.org/10.1177/0748233712457438