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Unique prognostic factors in acral lentiginous melanoma.
- Source :
-
American journal of surgery [Am J Surg] 2012 Dec; Vol. 204 (6), pp. 874-9; discussion 879-80. Date of Electronic Publication: 2012 Sep 28. - Publication Year :
- 2012
-
Abstract
- Background: This study was performed to identify clinicopathologic factors associated with survival in acral lentiginous melanoma.<br />Methods: A post hoc analysis of a prospective clinical trial and local database was performed in all patients with acral lentiginous melanomas. Multivariate analyses of factors associated with a tumor-positive sentinel lymph node (SLN) biopsy, disease-free survival (DFS), overall survival (OS), and local and in-transit recurrence-free survival (LITRFS) were performed. Kaplan-Meier survival analyses were performed.<br />Results: Eighty-five patients were identified. Age younger than 59 years and Breslow thickness (BT) of 2.0 mm or greater were independent risk factors for a positive SLN. SLN status was the only independent risk factor for DFS and LITRFS on multivariate analysis. A BT of 2.0 mm or greater was the only independent risk factor for OS. SLN status distinguished differences in DFS, OS, and LITRFS on Kaplan-Meier analysis.<br />Conclusions: SLN status is the dominant factor for recurrence and survival in acral lentiginous melanoma. BT and ulceration are less important in this histologic subtype.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Female
Follow-Up Studies
Humans
Lymphatic Metastasis
Male
Melanoma pathology
Melanoma surgery
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local
Prognosis
Retrospective Studies
Risk Factors
Sentinel Lymph Node Biopsy
Skin Neoplasms pathology
Skin Neoplasms surgery
Survival Analysis
Young Adult
Melanoma mortality
Skin Neoplasms mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1883
- Volume :
- 204
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 23022254
- Full Text :
- https://doi.org/10.1016/j.amjsurg.2012.05.013