Back to Search
Start Over
The influence of pain on cerebral functioning after mild traumatic brain injury.
- Source :
-
Journal of neurotrauma [J Neurotrauma] 2012 Nov 20; Vol. 29 (17), pp. 2625-34. Date of Electronic Publication: 2012 Oct 31. - Publication Year :
- 2012
-
Abstract
- More than 75% of patients with mild traumatic brain injury (MTBI) report chronic pain whose potential detrimental effects on cognitive recovery need to be identified. The objective of this study was to investigate the relationship between pain, performance on a working memory task, gray matter density, and mid-dorsolateral prefrontal cortex (mid-DLPFC) activation in subjects with a MTBI. For comparison purposes, we performed identical correlation analyses with a group of subjects without MTBI who sustained sports injuries. Twenty-four subjects who experienced a MTBI in the past 12 months, 16 control subjects, and 29 subjects with sport injuries were included. One hour prior to entering the magnetic resonance scanner, the subjects were asked to fill out the pain Visual Analogue Scale. Subsequently, a high-resolution T1-weighted image was acquired followed by a functional magnetic resonance imaging session using the visual externally ordered working memory task. Results showed that MTBI subjects reporting severe pain in the hour preceding the testing had reduced mid-DLPFC activation during the working memory task and poorer performance on the task. Subjects with sport injuries and severe levels of pain showed the reverse pattern: pain was associated with higher activation in the mid-DLPFC and did not correlate with performance. Gray matter density measures were independent of pain level. This study showed that behavioral performance and cerebral functioning are affected by pain after a MTBI. Moreover, this study suggests that pain, cognition, and cerebral functioning interactions could not easily be generalized from one clinical population to another.
- Subjects :
- Adult
Athletic Injuries pathology
Athletic Injuries physiopathology
Athletic Injuries psychology
Brain pathology
Brain Concussion pathology
Brain Injuries pathology
Depression psychology
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Memory, Short-Term physiology
Oxygen blood
Pain Measurement
Psychiatric Status Rating Scales
Psychomotor Performance physiology
Surveys and Questionnaires
Young Adult
Brain physiopathology
Brain Injuries physiopathology
Brain Injuries psychology
Pain physiopathology
Pain psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1557-9042
- Volume :
- 29
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Journal of neurotrauma
- Publication Type :
- Academic Journal
- Accession number :
- 23016544
- Full Text :
- https://doi.org/10.1089/neu.2012.2312