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[Antiherpetic activity of netropsin derivatives as tested in experiments in laboratory animals].

Authors :
Andronova VL
Grokhovskiĭ SL
Deriabin PG
Gurskiĭ GV
Galegov GA
L'vov DK
Source :
Voprosy virusologii [Vopr Virusol] 2012 Jul-Aug; Vol. 57 (4), pp. 24-6.
Publication Year :
2012

Abstract

Two dimeric netropsin derivatives (Lys-bis-Nt 15Lys-bis-Nt) were comprehensively tested for antiviral and toxic activity in cell cultures and laboratory animals. The two compounds were found to provide effective and selective inhibition of reproduction of herpes simplex I both in cell culture Vero E6 and in brain of infected white mice, thereby increasing the survival rate and mean life expectation of treated animals as compared to control.

Details

Language :
Russian
ISSN :
0507-4088
Volume :
57
Issue :
4
Database :
MEDLINE
Journal :
Voprosy virusologii
Publication Type :
Academic Journal
Accession number :
23012980