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Remogliflozin etabonate, a selective inhibitor of the sodium-glucose transporter 2, improves serum glucose profiles in type 1 diabetes.
- Source :
-
Diabetes care [Diabetes Care] 2012 Nov; Vol. 35 (11), pp. 2198-200. Date of Electronic Publication: 2012 Sep 25. - Publication Year :
- 2012
-
Abstract
- Objective: Remogliflozin etabonate (RE), an inhibitor of the sodium-glucose transporter 2, improves glucose profiles in type 2 diabetes. This study assessed safety, tolerability, pharmacokinetics, and pharmacodynamics of RE in subjects with type 1 diabetes.<br />Research Design and Methods: Ten subjects managed with continuous subcutaneous insulin infusion were enrolled. In addition to basal insulin, subjects received five randomized treatments: placebo, prandial insulin, 50 mg RE, 150 mg RE, and mg RE 500.<br />Results: Adverse events and incidence of hypoglycemia with RE did not differ from placebo and prandial insulin groups. RE significantly increased urine glucose excretion and reduced the rise in plasma glucose concentration after oral glucose. RE reduced incremental adjusted weighted mean glucose (0-4 h) values by 42-49 mg/dL and mean glucose (0-10 h) by 52-69 mg/dL.<br />Conclusions: RE can be safely administered with insulin in type 1 diabetes and reduces plasma glucose concentrations compared with placebo.
- Subjects :
- Adult
Diabetes Mellitus, Type 1 blood
Female
Glucosides administration & dosage
Humans
Hypoglycemic Agents administration & dosage
Insulin administration & dosage
Insulin therapeutic use
Male
Middle Aged
Pyrazoles administration & dosage
Blood Glucose drug effects
Diabetes Mellitus, Type 1 drug therapy
Glucosides therapeutic use
Hypoglycemic Agents therapeutic use
Pyrazoles therapeutic use
Sodium-Glucose Transporter 2 Inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1935-5548
- Volume :
- 35
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 23011728
- Full Text :
- https://doi.org/10.2337/dc12-0508