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Role of GB virus C in HIV-1-infected and hepatitis C virus-infected hemophiliac children and adolescents.
- Source :
-
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2012 Oct 01; Vol. 61 (2), pp. 243-8. - Publication Year :
- 2012
-
Abstract
- Background: GB Virus C (GBV-C) has been associated with a better prognosis of HIV-1 disease in adults. Little is known about prevalence and interaction between GBV-C, HIV-1, and/or hepatitis C virus (HCV) in hemophiliac children and adolescents.<br />Methods: A well-characterized cohort of HIV-1-infected and HIV-1-uninfected hemophiliac children and adolescents followed in the Hemophilia Growth and Development Study (HGDS) were evaluated using quantitative reverse transcription polymerase chain reaction to detect GBV-C RNA in samples from baseline and last follow-up visit.<br />Results: HIV-1-infected (n = 202) and HIV-1-uninfected (n = 119) patients had a low prevalence of GBV-C infection at baseline (0.9 and 0%), which increased at time of last follow-up visit to 25.2% and 26.3%, respectively. In addition, at the time of the follow-up GBV-C measurement, those GBV-C infected had been followed longer and had higher CD4(+) cell counts and lower HIV-1 viral loads than those GBV-C uninfected. These beneficial effects of GBV-C were no longer significant after controlling for CD4(+) cell count and HIV-1 RNA at baseline. HCV RNA clearance was more common amongst those who were not GBV-C infected than those who became GBV-C viremic.<br />Conclusions: This study confirms a positive association of GBV-C with milder course of HIV-1 infection. GBV-C infection was associated with a higher likelihood of persistent HCV infection.
- Subjects :
- Adolescent
Child
Cohort Studies
Female
HIV Infections pathology
Hepatitis, Viral, Human virology
Humans
Male
Prevalence
RNA, Viral blood
Real-Time Polymerase Chain Reaction
Young Adult
GB virus C isolation & purification
HIV Infections complications
Hemophilia A complications
Hepatitis C, Chronic complications
Hepatitis, Viral, Human epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1944-7884
- Volume :
- 61
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes (1999)
- Publication Type :
- Academic Journal
- Accession number :
- 23007118
- Full Text :
- https://doi.org/10.1097/qai.0b013e31826218e1.